Table II.
Identification of different ACE-inhibiting peptides in cheese.
| Cheese | Peptides | Reference |
|---|---|---|
| Crescenzaa | LVYPFPGPIHNSLPQ (β-CN (f58–72)) | [118] |
| Festivob | RPKHPI, RPKHPIK, RPKHPIKHQ (αs1-CN (f1–6), (f1–7), (f1–9)) | [102] |
| Goudaa | RPKHPIKHQ, RPKHPIKHQGLPQ (αs1-CN (f1–9), (f1–13)), YPFPGPIPN, MPFPKYPVQPf (β-CN (f60–68), (f109–119)) | [105] |
| Manchegoa | VVAPFPE, FPE, VPSERYL, KKYNVPQ (αs1-CN (f24–30), (f28–30), (f86–92), (f102–108)), TQPKTNAIPY, IPY (αs2-CN (f195–204), (f202–204)), VPKVKE, VPKVKET, VRGPFP (β-CN (f95–100), (f95–101), (f199–204)) | [32] |
| Manchegoa | VPSERYL, KKYNVPQL (αs1-CN (f86–92), (f102–109)), VRYL (αs2-CN (f205–208)), DKIHPF, LPQNILP (β-CN (f47–52), (f70–76)) + other peptides with IC50 values higher than 500 μM | [33] |
| Manchegoa | QP, PP, FP, PFP (various fragments), HPIK, HQGL (αs1-CN (f4–7), (f8–11)), DKIHP, DKIHPF, TGPIPN (β-CN (f47–51), (f47–52), (f63–68)) | [35] |
| Roncala | QP, PP (various fragments), RPKHP, PKHP, HPIK, HQGL (αs1-CN (f1–5), (f2–5), (f4–7), (f8–11)), DKIHP, DKIHPF, GPVR (β-CN (f47–51), (f47–52), (f197–200)) | [35] |
| Idiazábala | QP, FP (various fragments), NINE, PSE, ERYL, PQL, EIVPK, AWY (αs1-CN (f36–39), (f87–89), (f89–92), (f107–109), (f110–114), (f163–165)), DKIHP, DKIHPF (β-CN (f47–51), (f47–52)) | [35] |
| Mahóna | PK, PQ, RI/RL (various fragments), PQEVL, EVLN, NENLL, ENLL, NLLRF (αs1-CN (f12–16), (f14–17), (f17–21), (f18–21), (f19–23)) | [35] |
| Goat cheesea | QP, PP (various fragments), RPK (αs1-CN (f1–3)), EEL/EEI (β-CN (f4–7)/αs2-CN (f68–70)), DKIHP, DKIHPF, PLTQTP, VVVPP, GVPK, TDVEK, VRGP (β-CN (f47–51), (f47–52), (f76–81), (f82–86), (f94–97), (f128–132), (f201–204)) | [35] |
| Cabralesa | PP, MPI/MPL, EVVR (various fragments), REL, DKIHP, DKIHPF, FPGPIH, PGPIH, GPIH, PVEP, PVEPF (β-CN (f1–3), (f47–51), (f47–52), (f62–67), (f63–67), (f64–67), (f115–118), (f115–119)) | [35] |
| Cheese-like system of ovine milka , c | VPKVK, YQEP, YQEPVLGP (β-CN (f95–99), (f191–194), (f191–198)) + three peaks with sequence not determined | [115] |
| Cheese-like system of caprine milka , c | RPK, RPKHPIKH (αs1-CN (f1–3), (f1–8)), YQKFPQY (αs2-CN (f90–96)), VPKVK, YQEP, YQEPVLGP (β-CN (f95–99), (f191–194), (f191–198)), + six peaks with sequence not determined | [115] |
| Many different Swiss cheesesa | IPP, VPP (β-CN (f74–76), (f84–86)) | [15, 16] |
| Cheddara | RPKHPI, RPKHPIK, RPKHPIKHQ (= fraction 9), FVAPFPEVF, KKYKVPQLE (= fraction 27) (αs1-CN (f1–6), (f1–7), (f1–9), (f24–32), (f102–110)), DKIHPF (= fraction 15), YQEPVLGPVRGPFPIIV (= fraction 28) (β-CN (f47–52), (f193–209)) | [86] |
| Cheddara | ARHPHPH (= fraction 1) (κ-CN (f96–102)), RPKHPI, RPKHPIK, RPKHPIKHQ (= fraction 4), FVAPFPEVF (= fraction 15) (αs1-CN (f1–6), (f1–7), (f1–9), (f24–32)), YQEPVLGPVRGPFPIIV (= fraction 16) (β-CN (f193–209)) | [88] |
| Enzyme-modified cheese | LQP, MAP (β-CN (f88–90), (f102–104)) | [125] |
One-letter abbreviations of amino acids: A = alanine, C = cysteine, D = asparagic acid, E = glutamic acid, F = phenylalanine, G = glycine, H = histidine, I = isoleucine, K = lysine, L = leucine, M = methionine, N = asparagine, P = proline, Q = glutamine, R = arginine, S = serine, T = threonine, V = valine, W = tryptophan and Y = tyrosine.