Understanding lactose behaviour during storage by monitoring surface energy change using inverse gas chromatography

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Table II.

Comparison of surface heterogeneity profile parameters of coarse lactose and micronized lactose before and after storage at 75% RH for three months.

Probes	Lactose samples	Surface heterogeneity profile parameters
Probes	Lactose samples	Mode	AUC	Peak adsorption potential
Heptane	Coarse lactose	No change	Decreased	Minor right shift
Heptane	Micronized lactose	No change	Decreased	No shift
Dicholoromethane	Coarse lactose	No change	Decreased	No shift
Dicholoromethane	Micronized lactose	No change	No change	Right shift
Ethyl acetate	Coarse lactose	No change	No change	No shift
Ethyl acetate	Micronized lactose	No change	No change	Minor left shift