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Table I.
Particle size distribution parameters of coarse lactose and micronized lactose before and after storage at 75% RH (n = 3, data are shown as mean ± standard deviation) (d 10, d 50 and d 90 indicate 10%, 50% and 90% of the volume of particles are less than these particle sizes, respectively).
| Particle size parameter | Coarse lactose |
Micronized lactose |
||
|---|---|---|---|---|
| Before storage | After storage | Before storage | After storage | |
| d 10 (μm) | 84.8 ± 2.3 | 81.0 ± 4.2 | 0.8 ± 0.1 | 1.3 ± 0.1 |
| d 50 (μm) | 127.5 ± 3.8 | 125.0 ± 5.2 | 2.4 ± 0.2 | 3.1 ± 0.2 |
| d 90 (μm) | 192.0 ± 5.5 | 191.0 ± 6.1 | 5.0 ± 0.1 | 5.6 ± 0.3 |
| Span | 0.8 ± 0.1 | 0.9 ± 0.1 | 1.8 ± 0.1 | 1.4 ± 0.1 |