The effect of Lactobacillus rhamnosus HN001 on mineral absorption and bone health in growing male and ovariectomised female ratsEffet de Lactobacillus rhamnosus HN001 sur l'absorption minérale et la santé osseuse chez le rat mâle en croissance et la ratte ovariectomisée.

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Table III.

Baseline and final in vivo bone density and biochemical markers of bone turnover in rat plasma after being fed with L. rhamnosus HN001 for 12 weeks. Values are given as mean (SEM). Sham, sham-operated group (n = 10); OVX, ovariectomised group (n = 15); HN001, ovariectomised group fed with HN001 (n = 15).

Parameter	Week	Sham	OVX	HN001
CTx (ng·mL⁻¹)	12	2.12 (0.39)^a	3.63 (0.58)^b	4.15 (0.61)^b
Osteocalcin (ng·mL⁻¹)	12	72.9 (8.8)^a	184.6 (10.6)^b	152.3 (20.8)^b
Lumbar spine BMC (g)	−2	0.549 (0.021)^a	0.509 (0.017)^a	0.533 (0.031)^a
	4	0.549 (0.024)^a	0.499 (0.017)^b	0.508 (0.026)^b
	12	0.557 (0.021)^a	0.456 (0.016)^b	0.482 (0.021)^c
Lumbar spine BMD (g·cm⁻²)	−2	0.253 (0.005)^a	0.245 (0.017)^a	0.253 (0.005)^a
	4	0.248 (0.015)^a	0.234 (0.015)^a	0.234 (0.018)^a
	12	0.246 (0.005)^a	0.214 (0.006)^b	0.225 (0.005)^c
Femur BMC (g)	−2	0.572 (0.013)^a	0.546 (0.012)^a	0.563 (0.019)^a
	4	0.571 (0.045)^a	0.530 (0.035)^b	0.552 (0.065)^a
	12	0.586 (0.014)^a	0.509 (0.010)^b	0.545 (0.018)^c
Femur BMD (g·cm⁻²)	−2	0.352 (0.006)^a	0.341 (0.005)^a	0.346 (0.006)^a
	4	0.348 (0.006)^a	0.322 (0.005)^b	0.328 (0.006)^b
	12	0.350 (0.006)^a	0.307 (0.005)^b	0.318 (0.004)^c

Values with different superscripts (a, b and c) in a row are significantly different at P < 0.05. CTx, C-terminal telopeptides of Type 1 collagen; BMC, bone mineral content; BMD, bone mineral density.